The electrophysiology of cardiac and related cells can be described by a
series of mathematical equations. These equations in general cannot be solved
analytically, but computers can be used to calculate their solution over time.
Different models use different equations to account for differences
among different species and regions of the heart,
to reproduce particular experimental data,
and to test the applicability of different physiological mechanisms,
among other reasons.
The list below contains several examples of models of cardiac and related
cells ranging from simple to more biophysically detailed.
- Simplified Models
- Ionic Models (Neural)
Heart Models
- Ionic Models (SinoAtrial)
- Ionic Models (Atrial)
- Ionic Models (Purkinje)
- Ionic Models (Ventricle)
- Beeler-Reuter (generic ventricular cell, 1977)
- Luo-Rudy model, version 1 (guinea pig ventricular
cell, 1991 )
- Luo-Rudy model, “dynamic”
version (guinea pig ventricular cell, 2001)
-
Fox-McHarg-Gilmour
model (canine ventricular cell, 2002)
-
Hund-Rudy
model (dog ventricular cell, 2004)
-
Priebe-Beuckelmann model
(human ventricular cell, 1998)
-
Bernus-Wilders-Zemlin-Verschelde-Panfilov model
(reduced Priebe-Beuckelmann,
human ventricular cell, 2002)
-
ten Tusscher-Noble-Noble-Panfilov model
(human ventricular cells [epicardial, myocardial, and endocardial], 2004)
-
Iyer-Mazhari-Winslow model
(human ventricular cell, 2004)
-
Minimal model (human ventricular cells [epicardial, myocardial and endocardial], 2008)