Zhang-Holden-Kodama-Honjo-Lei-Varghese-Boyett Model
rabbit central sinoatrial cell


This applet is used to simulate the activation of rabbit central sinoatrial node myocytes using the Zhang et al. model.

To use the applet, click the Start button to initiate the simulation and the Reset button to return the parameters to their initial values. Check the box for each variable to plot it in the window. The final action potential duration (APD) and diastolic interval (DI) are calculated automatically. Press the Plot Currents button to view the individual transmembrane currents.

Things to try:

  • Check the effects of blocking some of the currents (from 0% to 100%).
  • After pressing the Plot Currents button, check the Ascii data box to obtain the voltage signal as a function of time. (Note that the larger the signal, the longer it takes for the window to appear.)

    Zhang H, Holden AV, Kodama I, Honjo H, Lei M, Varghese T, Boyett MR. (2000) Am J Physiol Heart Circ Physiol 279, H397-H421.