Di Francesco-Noble Model

for one Purkinje cell

This model is used to simulate the activation of Purkinje cells using the model of DiFrancesco and Noble.

To use the applet, click the Start button to initiate the simulation and the Reset button to return the parameters to their initial values. Check the box for each variable to plot it in the window. The final action potential duration (APD) and diastolic interval (DI) are calculated automatically. Press the Plot Currents button to view the individual transmembrane currents.

S1 and S2 indicate the timing of the first and second stimuli, respectively.

Things to try:

Uncheck the Voltage box and check the boxes for some of the other variables.

Change the values of gna to 80 and time to 30000 to see alternans of action potential duration.

After pressing the Plot Currents button, check the Ascii data box to obtain the voltage signal as a function of time. (Note that the larger the signal, the longer it takes for the window to appear.)

DiFrancesco R, Noble D. (1985) A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Phil Trans R Soc Lond B 307, 353-398.