Iyer-Mazhari-Winslow Model
for one human ventricular cell

This model is used to simulate the activation of human ventricular cells using the model of Iyer et al.

To use the applet, click the Start button to initiate the simulation and the Reset button to return the parameters to their initial valcalculated automatically. Press the Plot Currents button to view the individual transmembrane currents.

N(s1's) indicates the number of stimuli ues. Check the box for each variable to plot it in the window. The final action potential duration (APD) and diastolic interval (DI) are given at the cycle length indicated by S1 (bcl). S2 indicates the timing of the last stimulus.

Things to try:

  • Uncheck the Voltage box and check the boxes for some of the other variables.
  • Change N(S1's), S1, and S2 to calculate points on APD restitution curves.
  • After pressing the Plot Currents button, check the Ascii data box to obtain the voltage signal as a function of time. (Note that the larger the signal, the longer it takes for the window to appear.)

    Iyer V, Mazhari R, Winslow RL. (2004) Biophys J 87, 1507-1525.