Courtemanche-Ramirez-Nattel Model
for one human atrial cell

This model is used to simulate the activation of human atrial cells using the model of Courtemanche et al.

To use the applet, click the Start button to initiate the simulation and the Reset button to return the parameters to their initial values. Check the box for each variable to plot it in the window. The final action potential duration (APD) and diastolic interval (DI) are calculated automatically. Press the Plot Currents button to view the individual transmembrane currents.

S1 and S2 indicate the timing of the first and second stimuli, respectively.

Things to try:

  • Uncheck the Voltage box and check the boxes for some of the other variables.
  • Change S1 and S2 to calculate points on APD restitution curves.
  • After pressing the Plot Currents button, check the Ascii data box to obtain the voltage signal as a function of time. (Note that the larger the signal, the longer it takes for the window to appear.)

    Courtemanche M, Ramirez RJ, Nattel S. (1998) Am J Physiol 275, H301-H321.