cardiac dynamics articles and publications sprial waves scroll waves reentry Publications

Publications (pdf format)

Peer-reviewed Articles

  • 37) Luther S*, Fenton FH*, Kornreich BG, Squires A, Bittihn P, Hornung D, Zabel M, Flanders J, Gladuli A, Campoy L, Cherry EM, Luther G, Hasenfuss G, Krinsky VI, Pumir A, Gilmour RF Jr, Bodenschatz E.
    "Low-energy control of electrical turbulence in the heart." Nature. Jul 13;475(7355):235-9; 2011 (*) Equal first authors.

  • 36) Cherry EM, Fenton FH
    "Effects of boundaries and geometry on the spatial distribution of action potential duration in cardiac tissue" Journal of Theoretical Biology Vol 285, 164-176, 2011

  • 35) Bartocci E, Cherry EM, Glimm J, Grosu R, Smolka SA, Fenton FH
    "Toward Real-time Simulation of Cardiac Dynamics", CMSB 2011 9th International Conference on Computational Methods in Systems Biology, Sept. 21-23 pages 103-110. ACM, 2011.

  • 34) Murthy A, Bartocci E, Fenton FH, Glimm J, Gray RA, Smolka SA, and Grosu R
    "Curvature Analysis of Cardiac Excitation Wavefronts", CMSB 2011 9th International Conference on Computational Methods in Systems Biology, Sept. 21-23 pages 151-160. ACM, 2011.

  • 33)Grosu R, Batt G, Fenton FH, Glimm J, Le Guernic C, Smolka SA, Bartocci E
    "From Cardiac Cells to Genetic Regulatory Networks" International Conference on Computer Aided Verification 6806, pp. 396-411, 2011

  • 32)Niederer SA, Kerfoot E, Benson A, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A, Heidenreich E, Land S, Maleckar M, Pathmanathan P, Plank G, Rodriguez JF, Roy I, Sachse FB, Seemann G, Skavhaug O, Smith NP.
    "Verification of cardiac tissue electrophysiology simulations using an N-version benchmark". Transactions of the Royal Society A, in press

  • 31)Clayton RH, Bernus O; Cherry EM; Dierckx H; Fenton FH, Mirabella L, Panfilov S V, Sachse FB, Seeman G; Zhang H.
    "Models of cardiac tissue electrophysiology: Progress, challenges and open questions" Prog Biophys Mol Biol 2011;104; 22-48

  • 30)Fink M, Niederer SA, Cherry EM, Fenton FH, Koivumäki JT, Seemann G, Thul R, Zhang H, Sachse FB, Beard D, Crampin EJ, Smith NP.
    " Cardiac cell modeling: Observations from the heart of the cardiac physiome project", Prog Biophys Mol Biol, 2011, 104; 2-21

  • 29) Fenton FH,
    "The Value of Simulation" Physics World 23:46-47 2010.

  • 28) Cherry EM and Fenton FH,
    "Realistic cardiac electrophysiology modeling: are we just a heartbeat away?" J. Physiol. 588, 2689; 2010

  • 27)Fenton FH, Luther S, Otani NF, Cherry EM, Pumir A, Bodenschatz E, Krinsky V, Gilmour RF Jr.
    Termination of atrial fibrillation using pulsed low-energy far field stimulation Circulation 120, 467-476: 2009.

  • 26)Otani NF, Singh R, Fenton FH, Butcher J, DW Infanger DW, Neumann A, Luther S, Gilmour Jr RF
    Use of Ultrasound Imaging to Map Propagating Action Potential Waves in the Heart Computers in cardiology 2009.

  • 25) Garzon A, Roman OG, Fenton FH.
    Model-based control of cardiac alternans on a ring Physical Review E 2009;80:021932.

  • 24) Cherry EM, Fenton FH.
    Visualization of spiral and scroll waves in simulated and experimental cardiac tissue 2008; New J. Phys. 10 125016 (43pp). ( Selected as New Journal of Physics Best of 2008 by the editors)

  • 23) Fenton FH., Cherry EM
    Models of cardiac cell Scholarpedia. 2008; 3(8):1868

  • 21) Cherry EM, Evans SJ.
    Properties of two human atrial cell models in tissue: Restitution, memory, propagation, and reentry. Journal of Theoretical Biology, 2008; Oct 7;254(3):674-90

  • 22) Fenton FH, Cherry EM, Kornreich BG.
    Termination of equine atrial fibrillation by quinidine: An optical mapping study. Journal of Veterinary Cardiology 2008, 10 87-102. (Article featured in the Journal Cover)

  • 20) Cherry EM, Hastings HM, Evans SJ.
    Dynamics of human atrial cell models: Restitution, memory, and intracellular calcium dynamics in single cells. Progress in Biophysics and Molecular Biology 2008; 98: 24-37

  • 19) Otani NF, Mo A, Mannava S, Fenton FH, Cherry EM, Luther S, Gilmour RF, Jr..
    Predator-prey approach to analyzing complex dynamics in cardiac tissue 2008; Physical Review E 78, 021913

  • 18) Fenton FH., Cherry EM, Glass Leon.
    Cardiac arrhythmia Scholarpedia. 2008; 3(7):1665

  • 17) Bueno-Orovio A., Cherry EM, Fenton FH.
    Minimal Model for Human Ventricular Action Potential in Tissue Journal of Theoretical Biology 2008; 253: 544-560.

  • 16) Cherry EM., Ehrlich JR, Nattel S, Fenton FH.
    Pulmonary Vein Reentry-Properties and Size Matter: Insights from a Computational Analysis. Heart Rhythm 2007; 12: 1553-1562. (Article featured in the Journal Cover)

  • 15) Cherry EM, Fenton FH.
    A tale of two dogs: analyzing two models of canine ventricular electrophysiology American Journal of Physiology 2007; 292: H43-H55

  • 14) Bueno-Orovio A., Perez-Garcia VM., and Fenton FH.
    Spectral Methods for Partial Differential Equations in Irregular Domains: The Spectral Smoothed Boundary Method. SIAM Journal on Scientific Computing 2006; Vol. 28, N.3; 886-900;

  • 13) Fenton FH., Cherry EM., Karma A., Rappel WJ.
    Modeling Wave Propagation in Realistic Heart Geometries Using the Phase-Field Method. Chaos 2005; 15: 013502

  • 12) Cherry EM, Fenton FH.
    Suppression of Alternans and Conduction Blocks Despite Steep APD Restitution: Electrotonic, Memory and Conduction Velocity Restitution Effects. American Journal of Physiology 2004; 286: H2332-2341. ( supplemental material here )

  • 11) Cherry EM, Greenside HS, Henriquez CS.
    Efficient simulation of three-dimensional anisotropic cardiac tissue using an adaptive mesh refinement method. Chaos 2003; 13: 853-865.

  • 10) Fenton FH, Cherry EM, Hastings HM, Evans SJ.
    Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity. Chaos 2002; 12: 852-892. (supplemental material here )

  • 9) Fenton FH, Cherry EM, Hastings HM, Evans SJ.
    Real-time Computer Simulations of Excitable Media: Java as a Scientific Language and as a Wrapper for C and Fortran Programs. BioSystems 2002; 64: 73-96.

  • 8) Cherry EM, Xie F, Feliciano Z, Garfinkel A.
    Computer Modeling of Atrial Fibrillation. Cardiac Electrophysiology Review 2001; 5: 271-276.

  • 7) Watanabe M, Fenton F, Evans S, Hastings H, Karma A.
    Mechanisms for Discordant Alternans. Journal of Cardiovascular Electrophysiology 2001; 12: 196-206.

  • 6) Hastings H, Fenton F, Evans S, Hotomaroglu O, Geetha J, Gittelson K, Nilson J, Garfinkel A.
    Alternans and the Onset to Ventricular Fibrillation. Physical Review E 2000; 62: 4043-4048.

  • 5) Cherry EM, Greenside HS, Henriquez CS.
    A Space-Time Adaptive Method for Simulating Complex Cardiac Dynamics. Physical Review Letters 2000; 84: 1343-1346.

  • 4) Fenton F, Evans S, Hastings H.
    Memory in an excitable medium; A mechanism for spiral wave breakup in the low-excitability limit. Physical Review Letters 1999; 83: 3964-3967.

  • 3) Rappel WJ, Fenton F, Karma A.
    Spatiotemporal Control of Wave Instabilities in Cardiac Tissue. Physical Review Letters 1999; 83: 456-459.

  • 2) Fenton F, Karma A.
    Instability of Electrical Vortex Filament and Wave Turbulence in Thick Cardiac Muscle. Physical Review Letters 1998; 81: 481-484.

  • 1 ) Fenton F, Karma A.
    Vortex Dynamics in 3D Continuous Myocardium With Fiber Rotation: Filament Instability and Fibrillation. Chaos 1998; 8: 20-47. (Errata for table here: Chaos 1998; 8: 879.

    Peer-reviewed Abstracts

  • Cherry EM, Fenton FH, Hastings HM, Xie F, Garfinkel A, Weiss JN, Evans SJ.
    The Role of Decreased Conduction Velocity in the Initiation and Maintenance of Atrial Fibrillation in a Computer Model of Human Atria. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 538.

  • Fenton F, Cherry EM, Banville I, Gray RA, Hastings HM, Evans SJ.
    Validation of of Realistic 3D Computer Models of Ventricular Arrhythmias with Optical Mapping Experiments. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 538.

  • Garfinkel A, Fenton F, Xie F, Weiss JN, Feliciano Z, Boyle N, Evans SJ, Hastings H, Cherry E.
    The Effects of Electrical Restitution on the Stability of Scroll Wave Reentry in Simulated Human Atrium. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 538.

  • Xie F, Garfinkel A, Qu Z, Weiss JN, Fenton F, Evans SJ, Hastings H, Karma A, Cherry E.
    The Effect of Electrical Restitution on the Stability of Scroll Reentry in Anatomically Realistic Simulated Rabbit Ventricles. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 628.

  • Chen X, Fenton FH, Gray RA.
    Restitution Curves Can Not Predict the Dynamics in a Numerical Model of Reentry in a Ring. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 1024.

  • Cherry EM, Fenton FH, Hastings HM, Evans SJ.
    Differences in Reentry Dynamics Between Two Human Atrial Cell Models. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 985.

  • Cherry EM, Rappel WJ, Evans SJ, Fenton FH.
    Effects of Wall Heterogeneity in an Anatomically Realistic Model of Cardiac Ventricles: A Simulation Study. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 1109.
    Poster in pdf here

  • Fenton FH, Cherry EM, Hastings HM, Evans SJ.
    The APD Restitution Hypothesis Revised: Slope >1 Does Not Always Determine Alternans and Spiral Wave Breakup. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 1026.
    Poster in pdf here

  • Cherry EM, Ehrlich JR, Nattel S, Evans SJ, Fenton FH.
    Heterogeneous conduction in pulmonary veins: A model of atrial fibrillation due to slow reentrant circuits appearing as focal activity. Heart Rhythm 2004; 1: S85.

  • Fenton FH, Bueno Orovio A, Cherry EM, Evans SJ.
    Basis for the induction of phase two reentry in the Brugada syndrome: Insights from computer simulations. Heart Rhythm 2004; 1: S224-S225.
    Poster in pdf here

  • Fenton FH, Cherry EM, Ehrlich JR, Nattel S, Evans SJ.
    A simulation study of atrial fibrillation initiation: Differences in resting membrane potential can produce spontaneous activation at the pulmonary vein-left atrial junction. Heart Rhythm 2004; 1: S187-S188.
    Poster in pdf here

  • Fenton FH, Cherry EM, Gray RA, Hastings HM, Evans SJ.
    Fibrillation Without Alternans in Porcine Ventricles: Experiments, Theroy, and Numerical Simulations. Madrid Arrhythmias and Myocardium 2005;
    This poster won best Poster information here

    Conference Proceedings

  • Fenton F, Karma A, Hastings H, Evans S.
    Transition from Ventricular Tachycardia to Ventricular Fibrillation as a Function of Tissue Characteristics. IEEE Chicago 2000, World Congress on Medical Physics and Biomedical Engineering, CD-ROM, paper no. 5617-90379.

  • Fenton F.
    Numerical Simulations of Cardiac Dynamics. What can we learn from simple and complex models? Computers in Cardiology (IEEE) 2000; 27: 251-254.

  • Fenton F, Evans S, Hastings H, Karma.
    Transition from Ventricular Tachycardia to Ventricular Fibrillation as a Function of Tissue Characteristics in a Computer Model. Europace 2000 (Supplement D); 1: paper no. 109P/10. [Large poster.]

  • Hastings H, Whitman T, Evans S, Fenton F, Garfinkel A, Geetha J.
    Timing defibrillation shocks improves defibrillation succes.

  • Fenton FH, Cherry EM, Hastings HM, Evans SJ.
    Computers and arrhythmias: computational approaches to understanding cardiac electrical dynamics. Second MIT Conference on Computational Fluid and Solid Mechanics, 2003.

  • Bueno AO, Cherry EM, Perez-Garcia VM, Fenton FH.
    Efficient Integration Algorithms for Cardiac Tissue Simulations: Comparison of Pseudospectral, Spectral, Adaptive Mesh and ADI methods. Gordon Conference in Cardiac Arrhythmia Mechanisms 2003.