Publications (pdf format)
"Low-energy control of electrical turbulence in the heart." Nature. Jul 13;475(7355):235-9; 2011 (*) Equal first authors.
"Effects of boundaries and geometry on the spatial distribution of action potential duration in cardiac tissue" Journal of Theoretical Biology Vol 285, 164-176, 2011
"Toward Real-time Simulation of Cardiac Dynamics", CMSB 2011 9th International Conference on Computational Methods in Systems Biology, Sept. 21-23 pages 103-110. ACM, 2011.
"Curvature Analysis of Cardiac Excitation Wavefronts", CMSB 2011 9th International Conference on Computational Methods in Systems Biology, Sept. 21-23 pages 151-160. ACM, 2011.
"From Cardiac Cells to Genetic Regulatory Networks" International Conference on Computer Aided Verification 6806, pp. 396-411, 2011
"Verification of cardiac tissue electrophysiology simulations using an N-version benchmark". Transactions of the Royal Society A, in press
"Models of cardiac tissue electrophysiology: Progress, challenges and open questions" Prog Biophys Mol Biol 2011;104; 22-48
" Cardiac cell modeling: Observations from the heart of the cardiac physiome project", Prog Biophys Mol Biol, 2011, 104; 2-21
"The Value of Simulation" Physics World 23:46-47 2010.
"Realistic cardiac electrophysiology modeling: are we just a heartbeat away?" J. Physiol. 588, 2689; 2010
Termination of atrial fibrillation using pulsed low-energy far field stimulation Circulation 120, 467-476: 2009.
Use of Ultrasound Imaging to Map Propagating Action Potential Waves in the Heart Computers in cardiology 2009.
Model-based control of cardiac alternans on a ring Physical Review E 2009;80:021932.
Visualization of spiral and scroll waves in simulated and experimental cardiac tissue 2008; New J. Phys. 10 125016 (43pp). ( Selected as New Journal of Physics Best of 2008 by the editors)
Models of cardiac cell Scholarpedia. 2008; 3(8):1868
Properties of two human atrial cell models in tissue: Restitution, memory, propagation, and reentry. Journal of Theoretical Biology, 2008; Oct 7;254(3):674-90
Termination of equine atrial fibrillation by quinidine: An optical mapping study. Journal of Veterinary Cardiology 2008, 10 87-102. (Article featured in the Journal Cover)
Dynamics of human atrial cell models: Restitution, memory, and intracellular calcium dynamics in single cells. Progress in Biophysics and Molecular Biology 2008; 98: 24-37
Predator-prey approach to analyzing complex dynamics in cardiac tissue 2008; Physical Review E 78, 021913
Cardiac arrhythmia Scholarpedia. 2008; 3(7):1665
Minimal Model for Human Ventricular Action Potential in Tissue Journal of Theoretical Biology 2008; 253: 544-560.
Pulmonary Vein Reentry-Properties and Size Matter: Insights from a Computational Analysis. Heart Rhythm 2007; 12: 1553-1562. (Article featured in the Journal Cover)
A tale of two dogs: analyzing two models of canine ventricular electrophysiology American Journal of Physiology 2007; 292: H43-H55
Spectral Methods for Partial Differential Equations in Irregular Domains: The Spectral Smoothed Boundary Method. SIAM Journal on Scientific Computing 2006; Vol. 28, N.3; 886-900;
Modeling Wave Propagation in Realistic Heart Geometries Using the Phase-Field Method. Chaos 2005; 15: 013502
Suppression of Alternans and Conduction Blocks Despite Steep APD Restitution: Electrotonic, Memory and Conduction Velocity Restitution Effects. American Journal of Physiology 2004; 286: H2332-2341. ( supplemental material here )
Efficient simulation of three-dimensional anisotropic cardiac tissue using an adaptive mesh refinement method. Chaos 2003; 13: 853-865.
Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity. Chaos 2002; 12: 852-892. (supplemental material here )
Real-time Computer Simulations of Excitable Media: Java as a Scientific Language and as a Wrapper for C and Fortran Programs. BioSystems 2002; 64: 73-96.
Computer Modeling of Atrial Fibrillation. Cardiac Electrophysiology Review 2001; 5: 271-276.
Mechanisms for Discordant Alternans. Journal of Cardiovascular Electrophysiology 2001; 12: 196-206.
Alternans and the Onset to Ventricular Fibrillation. Physical Review E 2000; 62: 4043-4048.
A Space-Time Adaptive Method for Simulating Complex Cardiac Dynamics. Physical Review Letters 2000; 84: 1343-1346.
Memory in an excitable medium; A mechanism for spiral wave breakup in the low-excitability limit. Physical Review Letters 1999; 83: 3964-3967.
Spatiotemporal Control of Wave Instabilities in Cardiac Tissue. Physical Review Letters 1999; 83: 456-459.
Instability of Electrical Vortex Filament and Wave Turbulence in Thick Cardiac Muscle. Physical Review Letters 1998; 81: 481-484.
Vortex Dynamics in 3D Continuous Myocardium With Fiber Rotation: Filament Instability and Fibrillation. Chaos 1998; 8: 20-47. (Errata for table here: Chaos 1998; 8: 879.
The Role of Decreased Conduction Velocity in the Initiation and Maintenance of Atrial Fibrillation in a Computer Model of Human Atria. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 538.
Validation of of Realistic 3D Computer Models of Ventricular Arrhythmias with Optical Mapping Experiments. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 538.
The Effects of Electrical Restitution on the Stability of Scroll Wave Reentry in Simulated Human Atrium. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 538.
The Effect of Electrical Restitution on the Stability of Scroll Reentry in Anatomically Realistic Simulated Rabbit Ventricles. Pacing and Clinical Electrophysiology 2002 (Part II); 24: 628.
Restitution Curves Can Not Predict the Dynamics in a Numerical Model of Reentry in a Ring. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 1024.
Differences in Reentry Dynamics Between Two Human Atrial Cell Models. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 985.
Effects of Wall Heterogeneity in an Anatomically Realistic Model of Cardiac Ventricles: A Simulation Study. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 1109.
Poster in pdf here
The APD Restitution Hypothesis Revised: Slope >1 Does Not Always Determine Alternans and Spiral Wave Breakup. Pacing and Clinical Electrophysiology 2003 (Part II); 26: 1026.
Poster in pdf here
Heterogeneous conduction in pulmonary veins: A model of atrial fibrillation due to slow reentrant circuits appearing as focal activity. Heart Rhythm 2004; 1: S85.
Basis for the induction of phase two reentry in the Brugada syndrome: Insights from computer simulations. Heart Rhythm 2004; 1: S224-S225.
Poster in pdf here
A simulation study of atrial fibrillation initiation: Differences in resting membrane potential can produce spontaneous activation at the pulmonary vein-left atrial junction. Heart Rhythm 2004; 1: S187-S188.
Poster in pdf here
Fibrillation Without Alternans in Porcine Ventricles: Experiments, Theroy, and Numerical Simulations. Madrid Arrhythmias and Myocardium 2005;
This poster won best Poster information here
Transition from Ventricular Tachycardia to Ventricular Fibrillation as a Function of Tissue Characteristics. IEEE Chicago 2000, World Congress on Medical Physics and Biomedical Engineering, CD-ROM, paper no. 5617-90379.
Numerical Simulations of Cardiac Dynamics. What can we learn from simple and complex models? Computers in Cardiology (IEEE) 2000; 27: 251-254.
Transition from Ventricular Tachycardia to Ventricular Fibrillation as a Function of Tissue Characteristics in a Computer Model. Europace 2000 (Supplement D); 1: paper no. 109P/10. [Large poster.]
Timing defibrillation shocks improves defibrillation succes.
Computers and arrhythmias: computational approaches to understanding cardiac electrical dynamics. Second MIT Conference on Computational Fluid and Solid Mechanics, 2003.
Efficient Integration Algorithms for Cardiac Tissue Simulations: Comparison of Pseudospectral, Spectral, Adaptive Mesh and ADI methods. Gordon Conference in Cardiac Arrhythmia Mechanisms 2003.