Luo-Rudy Dynamic (LRd) Model for Ventricular Cells

One Cell

While the Beeler-Reuter applet and the Luo-Rudy-I applet show first generation ionic ventricular cell models, this LRd is a second generation model that includes formulation for most of the sarcolemmal currents, pumps and exchangers. The model implements cell compartmentalization (myoplasm, junctional and nonjunctional sarcoplasmic reticulum), Ca2+ buffers in the myoplasm (troponin, calmodulin) and in the junctional sarcoplasmic reticulum (calsequestrin), and calcium-induced Ca2+ release. It takes into account myoplasmic concentration changes of Na+ and K+ as well as Ca2+ concentration changes in all three compartments. For more detailed information visit Dr. Rudy's lab CBRTC and the official LRd model web site