This applet simulates a modified version of
a model for spontaneous oscillations during the aggregation stage of
Dictyostelium (Laub, M.T., and Loomis, W. F. (1998) A molecular network
that produces spontaneous oscillations in excitable cells of Dictyostelium.
Mol. Biol. Cell 9, 3521-3532.)
This page was built by Wouter-Jan Rappel. We thank
Flavio Fenton
who kindly provided us the Java applet.
To run the simulation, choose the coefficients k1 through k14 and the starting values of the [CAR1] etc. by typing them in the appropriate box and click on start. All seven variables can be plot by selecting them (click on the little box that appears to the left of their defenition). The results can be plotted either normalized (i.e. the values are rescaled so that the maximum value is 1) or not. The integration time can be chosen in the box "integration time=" in the upper right hand corner. If everything is set, click on "start". Integration can be continued by clicking on "integrate".
Brief description of the model:
The governing equations for the seven variable are given by
[ACA]' = k1[CAR1]-k2[ACA] |
[PKA]' = k3[cAMP_{i}]-k4[PKA] |
[ERK2]' = k5[CAR1]-k6[PKA][ERK2] |
[RegA]' = k7-k8[ERK2][RegA] |
[cAMP_{i}]' = k9[ACA]-k10[RegA][cAMP_{i}] |
[cAMP_{e}]' = k11[ACA]-k12[cAMP_{e}] |
[CAR1]' = k13[cAMP_{e}]-k14[PKA][CAR1] |
Where